Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged skin microenvironment. Using thi...

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Detalles Bibliográficos
Autores principales: Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899869/
https://www.ncbi.nlm.nih.gov/pubmed/27272654
http://dx.doi.org/10.1038/ncomms11762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899869/
https://www.ncbi.nlm.nih.gov/pubmed/27272654
http://dx.doi.org/10.1038/ncomms11762

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