Amphipathic β(2,2)-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia pneumoniae

We demonstrate in the current work that small cationic antimicrobial β(2,2)-amino acid derivatives (Mw < 500 Da) are highly potent against Chlamydia pneumoniae at clinical relevant concentrations (< 5 μM, i.e. < 3.4 μg/mL). C. pneumoniae is an atypical respiratory pathogen associated with f...

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Detalles Bibliográficos
Autores principales: Hanski, Leena, Ausbacher, Dominik, Tiirola, Terttu M., Strøm, Morten B., Vuorela, Pia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900588/
https://www.ncbi.nlm.nih.gov/pubmed/27280777
http://dx.doi.org/10.1371/journal.pone.0157306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900588/
https://www.ncbi.nlm.nih.gov/pubmed/27280777
http://dx.doi.org/10.1371/journal.pone.0157306

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