Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine

Cytotoxic drugs, such as nucleoside analogs and toxins, commonly suffer from off-target effects. One approach to mitigate this problem is to deliver the cytotoxic drug selectively to the intended site. While for toxins this can be achieved by conjugating the cell-killing moiety to a targeting moiety...

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Detalles Bibliográficos
Autores principales: Koduvayur, Sujatha P., Su, Ying, Kay, Brian K., Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900609/
https://www.ncbi.nlm.nih.gov/pubmed/27280468
http://dx.doi.org/10.1371/journal.pone.0157114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900609/
https://www.ncbi.nlm.nih.gov/pubmed/27280468
http://dx.doi.org/10.1371/journal.pone.0157114

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