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Short DNA Fragments Are a Hallmark of Heavy Charged-Particle Irradiation and May Underlie Their Greater Therapeutic Efficacy

Growing interest in proton and heavy ion therapy has reinvigorated research into the fundamental biological mechanisms underlying the therapeutic efficacy of charged-particle radiation. To improve our understanding of the greater biological effectiveness of high-LET radiations, we have investigated...

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Detalles Bibliográficos
Autores principales: Pang, Dalong, Chasovskikh, Sergey, Rodgers, James E., Dritschilo, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901041/
https://www.ncbi.nlm.nih.gov/pubmed/27376024
http://dx.doi.org/10.3389/fonc.2016.00130