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Update on Lynch syndrome genomics
Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6, and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of the most prevalent hereditary cancer syndromes in man and accounts for 1–3 % of unselected colorectal carcinomas and some 15 % of t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901089/ https://www.ncbi.nlm.nih.gov/pubmed/26873718 http://dx.doi.org/10.1007/s10689-016-9882-8 |