Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

AIMS/HYPOTHESIS: While the class I phosphoinositide 3-kinases (PI3Ks) are well-documented positive regulators of metabolism, the involvement of class II PI3K isoforms (PI3K-C2α, -C2β and -C2γ) in metabolic regulation is just emerging. Organismal inactivation of PI3K-C2β increases insulin signalling...

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Detalles Bibliográficos
Autores principales: Alliouachene, Samira, Bilanges, Benoit, Chaussade, Claire, Pearce, Wayne, Foukas, Lazaros C., Scudamore, Cheryl L., Moniz, Larissa S., Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901096/
https://www.ncbi.nlm.nih.gov/pubmed/27138914
http://dx.doi.org/10.1007/s00125-016-3963-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901096/
https://www.ncbi.nlm.nih.gov/pubmed/27138914
http://dx.doi.org/10.1007/s00125-016-3963-y

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