High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine

Approximately 15 % of colorectal carcinomas (CRC) display high level microsatellite instability (MSI-H) due to either a germline mutation in one of the genes responsible for DNA mismatch repair (Lynch syndrome, 3 %) or somatic inactivation of the same pathway, most commonly through hypermethylation...

Descripción completa

Detalles Bibliográficos
Autores principales: Gatalica, Zoran, Vranic, Semir, Xiu, Joanne, Swensen, Jeffrey, Reddy, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901118/
https://www.ncbi.nlm.nih.gov/pubmed/26875156
http://dx.doi.org/10.1007/s10689-016-9884-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901118/
https://www.ncbi.nlm.nih.gov/pubmed/26875156
http://dx.doi.org/10.1007/s10689-016-9884-6

Ejemplares similares