Cargando…

Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo

Atherosclerosis occurs preferentially in arterial regions exposed to disturbed blood flow. Targeting these pro-atherogenic regions is a potential anti-atherogenic therapeutic approach, but it has been extremely challenging. Here, using in vivo phage display approach and the partial carotid ligation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Jihwa, Shim, Hyunbo, Kim, Kwanchang, Lee, Duhwan, Kim, Won Jong, Kang, Dong Hoon, Kang, Sang Won, Jo, Hanjoong, Kwon, Kihwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901192/ https://www.ncbi.nlm.nih.gov/pubmed/27173134 http://dx.doi.org/10.1038/srep25636

Ejemplares similares

Arsenic Exposure Increases Monocyte Adhesion to the Vascular Endothelium, a Pro-Atherogenic Mechanism
por: Lemaire, Maryse, et al.
Publicado: (2015)

Ursodeoxycholic Acid (UDCA) Exerts Anti-Atherogenic Effects by Inhibiting RAGE Signaling in Diabetic Atherosclerosis
por: Chung, Jihwa, et al.
Publicado: (2016)

Ursodeoxycholic Acid (UDCA) Exerts Anti-Atherogenic Effects by Inhibiting Endoplasmic Reticulum (ER) Stress Induced by Disturbed Flow
por: Chung, Jihwa, et al.
Publicado: (2015)

The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1
por: Fledderus, Jolien, et al.
Publicado: (2021)

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
por: Al-aryahi, Sefaa, et al.
Publicado: (2014)

The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age
por: Walker, Ashley E., et al.
Publicado: (2019)

Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium
por: Maurizi, Eleonora, et al.
Publicado: (2022)

Pro-Atherogenic and Pro-Oxidant Diets Influence Semen and Blood Traits of Rabbit Bucks
por: Mattioli, Simona, et al.
Publicado: (2023)

NFκB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta
por: Vallejo, Abigail, et al.
Publicado: (2018)

Annexin A6 Polymorphism Is Associated with Pro-atherogenic Lipid Profiles and with the Downregulation of Methotrexate on Anti-Atherogenic Lipid Profiles in Psoriasis
por: Zhang, Fuxin, et al.
Publicado: (2022)

SUN-560 Simvastatin Inhibits the Pro-Inflammatory and Pro-Atherogenic Effects of Cream in Obese Subjects
por: Goyal, Itivrita, et al.
Publicado: (2020)

Association between atherogenic risk-modulating proteins and endothelium-dependent flow-mediated dilation in coronary artery disease patients
por: Tryfonos, Andrea, et al.
Publicado: (2022)

Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells
por: Mohan, Girish C., et al.
Publicado: (2017)

Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB
por: Pedrigi, Ryan M., et al.
Publicado: (2016)

Lipid Profiles Alter from Pro-Atherogenic into Less Atherogenic and Proinflammatory in Juvenile Idiopathic Arthritis Patients Responding to Anti TNF-α Treatment
por: Yeh, Kuo-Wei, et al.
Publicado: (2014)

A Sorbent with Synthetic Ligand for Removing Pro-atherogenic and Pro-inflammatory Components from Human Blood Plasma
por: Dmitrieva, O. A., et al.
Publicado: (2021)

In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role
por: Pemberton, Alan D., et al.
Publicado: (2010)

Biophysical and Biochemical Outcomes of Chlamydia pneumoniae Infection Promotes Pro-atherogenic Matrix Microenvironment
por: Evani, Shankar J., et al.
Publicado: (2016)

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
por: Vrieling, Frank, et al.
Publicado: (2018)

Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses
por: Stadler, Julia T., et al.
Publicado: (2022)

Atherogenic dyslipidemia
por: Manjunath, C. N., et al.
Publicado: (2013)

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs
por: Plens-Galaska, Martyna, et al.
Publicado: (2018)

NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program
por: Kempe, Sybille, et al.
Publicado: (2005)

Uremic Conditions Drive Human Monocytes to Pro-Atherogenic Differentiation via an Angiotensin-Dependent Mechanism
por: Trojanowicz, Bogusz, et al.
Publicado: (2014)

Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells
por: Oksaharju, Anna, et al.
Publicado: (2009)

NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
por: Karlsen, Tom Rune, et al.
Publicado: (2021)

Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles
por: Syed, Shahan, et al.
Publicado: (2021)

The pro-atherogenic effects of macrophages are reduced upon formation of a complex between C-reactive protein and lysophosphatidylcholine
por: Chang, Mi-Kyung, et al.
Publicado: (2012)

Targeting the Endothelium to Achieve Cardioprotection
por: Herrera-Zelada, Nicolas, et al.
Publicado: (2021)

Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells
por: Pek, Nicole Min Qian, et al.
Publicado: (2019)

Targeting skeletal endothelium to ameliorate bone loss
por: Xu, Ren, et al.
Publicado: (2018)

Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice
por: Liao, Birong, et al.
Publicado: (2008)

Pro-atherogenic mediators and subclinical atherogenesis are related to epicardial adipose tissue thickness in patients with cardiovascular risk
por: Peraza-Zaldívar, Juan A, et al.
Publicado: (2016)

Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice
por: Schuster, Susanne, et al.
Publicado: (2019)

Trained Immunity in Primary Sjögren’s Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype
por: Huijser, Erika, et al.
Publicado: (2022)

Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface
por: John, A., et al.
Publicado: (2020)

Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice
por: Lim, Haian, et al.
Publicado: (2016)

The Endothelium as a Target in Pediatric OSA
por: Kheirandish-Gozal, Leila
Publicado: (2012)

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
por: de Bruin, Ruben G., et al.
Publicado: (2016)

Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia
por: Cantin, Claudette, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j9e6q5q4qi196n6dh60cm62pls