Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese

We investigated the influence of gut microbiotal metabolism on the pharmacokinetics of berberine in healthy male Africans and Chinese. The C(max) and AUC in the Africans were 2.67-fold and 2.0-fold higher than the Chinese, respectively. Microbiotal compositions by 16S rRNA pyrosequencing showed high...

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Detalles Bibliográficos
Autores principales: Alolga, Raphael N., Fan, Yong, Chen, Zhuo, Liu, Li-Wei, Zhao, Yi-Jing, Li, Jin, Chen, Yan, Lai, Mao-De, Li, Ping, Qi, Lian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901288/
https://www.ncbi.nlm.nih.gov/pubmed/27283523
http://dx.doi.org/10.1038/srep27671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901288/
https://www.ncbi.nlm.nih.gov/pubmed/27283523
http://dx.doi.org/10.1038/srep27671

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