A faulty interaction between SOD1 and hCCS in neurodegenerative disease

A proportion of Amyotrophic lateral sclerosis (ALS) cases result from impaired mutant superoxide dismutase-1 (SOD1) maturation. The copper chaperone for SOD1 (hCCS) forms a transient complex with SOD1 and catalyses the final stages of its maturation. We find that a neurodegenerative disease-associat...

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Detalles Bibliográficos
Autores principales: Wright, Gareth S. A., Antonyuk, Svetlana V., Hasnain, S. Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901319/
https://www.ncbi.nlm.nih.gov/pubmed/27282955
http://dx.doi.org/10.1038/srep27691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901319/
https://www.ncbi.nlm.nih.gov/pubmed/27282955
http://dx.doi.org/10.1038/srep27691

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