Emerging Computational Methods for the Rational Discovery of Allosteric Drugs

[Image: see text] Allosteric drug development holds promise for delivering medicines that are more selective and less toxic than those that target orthosteric sites. To date, the discovery of allosteric binding sites and lead compounds has been mostly serendipitous, achieved through high-throughput...

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Detalles Bibliográficos
Autores principales: Wagner, Jeffrey R., Lee, Christopher T., Durrant, Jacob D., Malmstrom, Robert D., Feher, Victoria A., Amaro, Rommie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901368/
https://www.ncbi.nlm.nih.gov/pubmed/27074285
http://dx.doi.org/10.1021/acs.chemrev.5b00631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901368/
https://www.ncbi.nlm.nih.gov/pubmed/27074285
http://dx.doi.org/10.1021/acs.chemrev.5b00631

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