The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) and its selecti...

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Detalles Bibliográficos
Autores principales: NATHWANI, SEEMA-MARIA, GREENE, LISA M., BUTINI, STEFANIA, CAMPIANI, GIUSEPPE, WILLIAMS, D. CLIVE, SAMALI, AFSHIN, SZEGEZDI, EVA, ZISTERER, DANIELA M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902072/
https://www.ncbi.nlm.nih.gov/pubmed/27176505
http://dx.doi.org/10.3892/ijo.2016.3518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902072/
https://www.ncbi.nlm.nih.gov/pubmed/27176505
http://dx.doi.org/10.3892/ijo.2016.3518

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