Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy

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Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C(2)‐symmetric marine‐derived bis(lactone) disorazole C(1), a hig...

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Detalles Bibliográficos
Autores principales: Ralston, Kevin J., Ramstadius, H. Clinton, Brewster, Richard C., Niblock, Helen S., Hulme, Alison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Zuschriften
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902119/
https://www.ncbi.nlm.nih.gov/pubmed/27346897
http://dx.doi.org/10.1002/ange.201501922
Descripción
Sumario:Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C(2)‐symmetric marine‐derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.

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