Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy

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Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C(2)‐symmetric marine‐derived bis(lactone) disorazole C(1), a hig...

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Autores principales: Ralston, Kevin J., Ramstadius, H. Clinton, Brewster, Richard C., Niblock, Helen S., Hulme, Alison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Zuschriften
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902119/
https://www.ncbi.nlm.nih.gov/pubmed/27346897
http://dx.doi.org/10.1002/ange.201501922
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author Ralston, Kevin J.
Ramstadius, H. Clinton
Brewster, Richard C.
Niblock, Helen S.
Hulme, Alison N.
author_facet Ralston, Kevin J.
Ramstadius, H. Clinton
Brewster, Richard C.
Niblock, Helen S.
Hulme, Alison N.
author_sort Ralston, Kevin J.
collection PubMed
description Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C(2)‐symmetric marine‐derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.
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spelling pubmed-49021192016-06-22 Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy Ralston, Kevin J. Ramstadius, H. Clinton Brewster, Richard C. Niblock, Helen S. Hulme, Alison N. Angew Chem Weinheim Bergstr Ger Zuschriften Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C(2)‐symmetric marine‐derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process. WILEY‐VCH Verlag 2015-06-08 2015-04-29 /pmc/articles/PMC4902119/ /pubmed/27346897 http://dx.doi.org/10.1002/ange.201501922 Text en © 2015 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Open access.
spellingShingle Zuschriften
Ralston, Kevin J.
Ramstadius, H. Clinton
Brewster, Richard C.
Niblock, Helen S.
Hulme, Alison N.
Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title_full Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title_fullStr Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title_full_unstemmed Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title_short Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
title_sort self‐assembly of disorazole c(1) through a one‐pot alkyne metathesis homodimerization strategy
topic Zuschriften
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902119/
https://www.ncbi.nlm.nih.gov/pubmed/27346897
http://dx.doi.org/10.1002/ange.201501922
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