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Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1

The environmental and occupational carcinogen Hexavalent Chromium (Cr(VI)) has been shown to cause lung cancer in humans when inhaled. In spite of a considerable research effort, the mechanisms of Cr(VI)-induced carcinogenesis remain largely unknown. Nupr1 (nuclear protein 1) is a small, highly basi...

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Detalles Bibliográficos
Autores principales: Chen, Danqi, Kluz, Thomas, Fang, Lei, Zhang, Xiaoru, Sun, Hong, Jin, Chunyuan, Costa, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902237/
https://www.ncbi.nlm.nih.gov/pubmed/27285315
http://dx.doi.org/10.1371/journal.pone.0157317