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N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms

The most prominent hallmark of prion diseases is prion protein conversion and the subsequent deposition of the altered prions, PrP(Sc), at the pathological sites of affected individuals, particularly in the brain. A previous study has demonstrated that the N-terminus of the pathogenic prion isoform...

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Detalles Bibliográficos
Autores principales: Choi, Yeong-Gon, Shin, Hae-Young, Kim, Jae-Il, Choi, Eun-Kyoung, Carp, Richard I., Kim, Yong-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902843/
https://www.ncbi.nlm.nih.gov/pubmed/25983034
http://dx.doi.org/10.1007/s12035-015-9200-8