Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive and invasive of the breast cancer subtypes. TNBC is a challenging disease that lacks targets for treatment. Histone deacetylase inhibitors (HDACi) are a group of targeted anticancer agents that enhance radiosensitivity. Bcl-2/ad...

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Detalles Bibliográficos
Autores principales: Chiu, Hui-Wen, Yeh, Ya-Ling, Wang, Yi-Ching, Huang, Wei-Jan, Ho, Sheng-Yow, Lin, Pinpin, Wang, Ying-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902929/
https://www.ncbi.nlm.nih.gov/pubmed/27286975
http://dx.doi.org/10.1186/s12943-016-0531-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902929/
https://www.ncbi.nlm.nih.gov/pubmed/27286975
http://dx.doi.org/10.1186/s12943-016-0531-5

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