A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death

BACKGROUND: Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal death. Mitochondria play a critical role in neuroinflammation and the oxidative stress response. Mitochondrial morphology is disru...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hwajin, Lee, Jong Youl, Park, Keon Jae, Kim, Won-Ho, Roh, Gu Seob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902937/
https://www.ncbi.nlm.nih.gov/pubmed/27287829
http://dx.doi.org/10.1186/s12868-016-0270-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902937/
https://www.ncbi.nlm.nih.gov/pubmed/27287829
http://dx.doi.org/10.1186/s12868-016-0270-y

Ejemplares similares