Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR

Recurrent, reciprocal genomic disorders resulting from non-allelic homologous recombination (NAHR) between near-identical segmental duplications (SDs) are a major cause of human disease, often producing phenotypically distinct syndromes. The genomic architecture of flanking SDs presents a significan...

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Detalles Bibliográficos
Autores principales: Tai, Derek J. C., Ragavendran, Ashok, Manavalan, Poornima, Stortchevoi, Alexei, Seabra, Catarina M., Erdin, Serkan, Collins, Ryan L., Blumenthal, Ian, Chen, Xiaoli, Shen, Yiping, Sahin, Mustafa, Zhang, Chengsheng, Lee, Charles, Gusella, James F., Talkowski, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903018/
https://www.ncbi.nlm.nih.gov/pubmed/26829649
http://dx.doi.org/10.1038/nn.4235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903018/
https://www.ncbi.nlm.nih.gov/pubmed/26829649
http://dx.doi.org/10.1038/nn.4235

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