Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?

Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated pr...

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Autores principales: Velasquez, Manuel T, Ramezani, Ali, Raj, Dominic S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903078/
https://www.ncbi.nlm.nih.gov/pubmed/26024026
http://dx.doi.org/10.1038/ki.2015.78
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author Velasquez, Manuel T
Ramezani, Ali
Raj, Dominic S
author_facet Velasquez, Manuel T
Ramezani, Ali
Raj, Dominic S
author_sort Velasquez, Manuel T
collection PubMed
description Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated protein has been shown to be associated with increased risk of death from cardiac causes in patients with end-stage renal disease. The precise mechanism by which carbamylated proteins mediate toxicity in uremia needs further investigation.
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spelling pubmed-49030782016-06-11 Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime? Velasquez, Manuel T Ramezani, Ali Raj, Dominic S Kidney Int Article Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated protein has been shown to be associated with increased risk of death from cardiac causes in patients with end-stage renal disease. The precise mechanism by which carbamylated proteins mediate toxicity in uremia needs further investigation. 2015-06 /pmc/articles/PMC4903078/ /pubmed/26024026 http://dx.doi.org/10.1038/ki.2015.78 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Velasquez, Manuel T
Ramezani, Ali
Raj, Dominic S
Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title_full Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title_fullStr Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title_full_unstemmed Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title_short Urea and protein carbamylation in ESRD: Surrogate markers or partners in crime?
title_sort urea and protein carbamylation in esrd: surrogate markers or partners in crime?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903078/
https://www.ncbi.nlm.nih.gov/pubmed/26024026
http://dx.doi.org/10.1038/ki.2015.78
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