Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding

Tyrosine decarboxylase (TDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme and is mainly responsible for the synthesis of tyramine, an important biogenic amine. In this study, the crystal structures of the apo and holo forms of Lactobacillus brevis TDC (LbTDC) were determined. The LbTDC displays...

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Detalles Bibliográficos
Autores principales: Zhu, Haixia, Xu, Guochao, Zhang, Kai, Kong, Xudong, Han, Ruizhi, Zhou, Jiahai, Ni, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904194/
https://www.ncbi.nlm.nih.gov/pubmed/27292129
http://dx.doi.org/10.1038/srep27779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904194/
https://www.ncbi.nlm.nih.gov/pubmed/27292129
http://dx.doi.org/10.1038/srep27779

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