3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties

A series of 3-aryl-1-phenyl-1H-pyrazole derivatives was synthesized in good yield and assayed in vitro as inhibitors of the mice acetylcholinesterase (AChE) and two goat liver monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the compounds demonstrated a good AChE and selective MAO-B inhibi...

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Detalles Bibliográficos
Autores principales: Kumar, Ashwani, Jain, Sandeep, Parle, Milind, Jain, Neelam, Kumar, Parvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904743/
https://www.ncbi.nlm.nih.gov/pubmed/27298613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904743/
https://www.ncbi.nlm.nih.gov/pubmed/27298613

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