The complexity of life and death decisions in mitosis

The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic a...

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Detalles Bibliográficos
Autores principales: Diaz-Martinez, Laura A, Yu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904892/
https://www.ncbi.nlm.nih.gov/pubmed/27308420
http://dx.doi.org/10.4161/23723548.2014.969658
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author Diaz-Martinez, Laura A
Yu, Hongtao
author_facet Diaz-Martinez, Laura A
Yu, Hongtao
author_sort Diaz-Martinez, Laura A
collection PubMed
description The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.
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spelling pubmed-49048922016-06-15 The complexity of life and death decisions in mitosis Diaz-Martinez, Laura A Yu, Hongtao Mol Cell Oncol Author'S View The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways. Taylor & Francis 2014-12-01 /pmc/articles/PMC4904892/ /pubmed/27308420 http://dx.doi.org/10.4161/23723548.2014.969658 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Diaz-Martinez, Laura A
Yu, Hongtao
The complexity of life and death decisions in mitosis
title The complexity of life and death decisions in mitosis
title_full The complexity of life and death decisions in mitosis
title_fullStr The complexity of life and death decisions in mitosis
title_full_unstemmed The complexity of life and death decisions in mitosis
title_short The complexity of life and death decisions in mitosis
title_sort complexity of life and death decisions in mitosis
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904892/
https://www.ncbi.nlm.nih.gov/pubmed/27308420
http://dx.doi.org/10.4161/23723548.2014.969658
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