Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism

The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of aden...

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Detalles Bibliográficos
Autores principales: Zhou, Ge, Myers, Jeffrey N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904903/
https://www.ncbi.nlm.nih.gov/pubmed/27308343
http://dx.doi.org/10.4161/23723548.2014.963441
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author Zhou, Ge
Myers, Jeffrey N
author_facet Zhou, Ge
Myers, Jeffrey N
author_sort Zhou, Ge
collection PubMed
description The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.
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spelling pubmed-49049032016-06-15 Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism Zhou, Ge Myers, Jeffrey N Mol Cell Oncol Commentary The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism. Taylor & Francis 2014-12-23 /pmc/articles/PMC4904903/ /pubmed/27308343 http://dx.doi.org/10.4161/23723548.2014.963441 Text en © 2014 The Author(s). 2014 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Zhou, Ge
Myers, Jeffrey N
Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title_full Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title_fullStr Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title_full_unstemmed Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title_short Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
title_sort mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904903/
https://www.ncbi.nlm.nih.gov/pubmed/27308343
http://dx.doi.org/10.4161/23723548.2014.963441
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AT myersjeffreyn mutantp53exertsoncogenicfunctionsbymodulatingcancercellmetabolism

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