The novel partnership of L-GILZ and p53: a new affair in cancer?

A recent report from our laboratory reveals how long glucocorticoid-induced leucine zipper (L-Gilz) protein binds to p53 and mouse double minute 2 homolog (Mdm2), thus dissociating the p53/Mdm2 complex and activating p53 with subsequent activation of downstream genes p21 and p53 upregulated modulato...

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Autores principales: Ayroldi, Emira, Marchetti, Cristina, Riccardi, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905020/
https://www.ncbi.nlm.nih.gov/pubmed/27308427
http://dx.doi.org/10.4161/23723556.2014.975087
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author Ayroldi, Emira
Marchetti, Cristina
Riccardi, Carlo
author_facet Ayroldi, Emira
Marchetti, Cristina
Riccardi, Carlo
author_sort Ayroldi, Emira
collection PubMed
description A recent report from our laboratory reveals how long glucocorticoid-induced leucine zipper (L-Gilz) protein binds to p53 and mouse double minute 2 homolog (Mdm2), thus dissociating the p53/Mdm2 complex and activating p53 with subsequent activation of downstream genes p21 and p53 upregulated modulator of apoptosis (Puma). p53 activation appears to be the mechanism by which both basal and glucocorticoid (GC)-induced L-Gilz inhibits proliferation and induces antioncogenic activity in human cancer.
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spelling pubmed-49050202016-06-15 The novel partnership of L-GILZ and p53: a new affair in cancer? Ayroldi, Emira Marchetti, Cristina Riccardi, Carlo Mol Cell Oncol Author'S View A recent report from our laboratory reveals how long glucocorticoid-induced leucine zipper (L-Gilz) protein binds to p53 and mouse double minute 2 homolog (Mdm2), thus dissociating the p53/Mdm2 complex and activating p53 with subsequent activation of downstream genes p21 and p53 upregulated modulator of apoptosis (Puma). p53 activation appears to be the mechanism by which both basal and glucocorticoid (GC)-induced L-Gilz inhibits proliferation and induces antioncogenic activity in human cancer. Taylor & Francis 2014-12-01 /pmc/articles/PMC4905020/ /pubmed/27308427 http://dx.doi.org/10.4161/23723556.2014.975087 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Ayroldi, Emira
Marchetti, Cristina
Riccardi, Carlo
The novel partnership of L-GILZ and p53: a new affair in cancer?
title The novel partnership of L-GILZ and p53: a new affair in cancer?
title_full The novel partnership of L-GILZ and p53: a new affair in cancer?
title_fullStr The novel partnership of L-GILZ and p53: a new affair in cancer?
title_full_unstemmed The novel partnership of L-GILZ and p53: a new affair in cancer?
title_short The novel partnership of L-GILZ and p53: a new affair in cancer?
title_sort novel partnership of l-gilz and p53: a new affair in cancer?
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905020/
https://www.ncbi.nlm.nih.gov/pubmed/27308427
http://dx.doi.org/10.4161/23723556.2014.975087
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