PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis

We recently demonstrated that PKCλ/ι signaling is an important contributor to breast cancer development. Strikingly, PKCλ/ι signaling is also important to balance self-renewal versus differentiation in pluripotent stem cells and is essential for embryonic development. This commentary highlights some...

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Detalles Bibliográficos
Autores principales: Paul, Arindam, Paul, Soumen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905021/
https://www.ncbi.nlm.nih.gov/pubmed/27308429
http://dx.doi.org/10.4161/23723556.2014.975076
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author Paul, Arindam
Paul, Soumen
author_facet Paul, Arindam
Paul, Soumen
author_sort Paul, Arindam
collection PubMed
description We recently demonstrated that PKCλ/ι signaling is an important contributor to breast cancer development. Strikingly, PKCλ/ι signaling is also important to balance self-renewal versus differentiation in pluripotent stem cells and is essential for embryonic development. This commentary highlights some key functions of PKCλ/ι signaling that are integral to both normal development and cancer progression.
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spelling pubmed-49050212016-06-15 PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis Paul, Arindam Paul, Soumen Mol Cell Oncol Commentary We recently demonstrated that PKCλ/ι signaling is an important contributor to breast cancer development. Strikingly, PKCλ/ι signaling is also important to balance self-renewal versus differentiation in pluripotent stem cells and is essential for embryonic development. This commentary highlights some key functions of PKCλ/ι signaling that are integral to both normal development and cancer progression. Taylor & Francis 2015-02-25 /pmc/articles/PMC4905021/ /pubmed/27308429 http://dx.doi.org/10.4161/23723556.2014.975076 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Paul, Arindam
Paul, Soumen
PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title_full PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title_fullStr PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title_full_unstemmed PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title_short PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
title_sort pkcλ/ι signaling—a common node for normal cellular development and breast oncogenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905021/
https://www.ncbi.nlm.nih.gov/pubmed/27308429
http://dx.doi.org/10.4161/23723556.2014.975076
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