Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma

A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferati...

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Detalles Bibliográficos
Autores principales: Bageritz, Josephine, Goidts, Violaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905057/
https://www.ncbi.nlm.nih.gov/pubmed/27308351
http://dx.doi.org/10.4161/23723548.2014.964028
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author Bageritz, Josephine
Goidts, Violaine
author_facet Bageritz, Josephine
Goidts, Violaine
author_sort Bageritz, Josephine
collection PubMed
description A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state. This finding highlights the connection between cell cycle length and the stem-like tumor state.
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spelling pubmed-49050572016-06-15 Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma Bageritz, Josephine Goidts, Violaine Mol Cell Oncol Author's Views A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state. This finding highlights the connection between cell cycle length and the stem-like tumor state. Taylor & Francis 2014-12-23 /pmc/articles/PMC4905057/ /pubmed/27308351 http://dx.doi.org/10.4161/23723548.2014.964028 Text en © 2014 The Author(s). 2014 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Bageritz, Josephine
Goidts, Violaine
Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title_full Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title_fullStr Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title_full_unstemmed Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title_short Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
title_sort functional characterization of enpp1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905057/
https://www.ncbi.nlm.nih.gov/pubmed/27308351
http://dx.doi.org/10.4161/23723548.2014.964028
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