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G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905062/ https://www.ncbi.nlm.nih.gov/pubmed/27308425 http://dx.doi.org/10.4161/23723556.2014.975070 |