G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling

We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP inhibits medulloblastoma growth and augments inhibition of smoothened to decrease tumor cell proliferation, thus highlighting Gα(s) as a potential therapeutic target.