G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling

We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP i...

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Detalles Bibliográficos
Autores principales: He, Xuelian, Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905062/
https://www.ncbi.nlm.nih.gov/pubmed/27308425
http://dx.doi.org/10.4161/23723556.2014.975070
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author He, Xuelian
Lu, Q. Richard
author_facet He, Xuelian
Lu, Q. Richard
author_sort He, Xuelian
collection PubMed
description We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP inhibits medulloblastoma growth and augments inhibition of smoothened to decrease tumor cell proliferation, thus highlighting Gα(s) as a potential therapeutic target.
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spelling pubmed-49050622016-06-15 G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling He, Xuelian Lu, Q. Richard Mol Cell Oncol Author'S View We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP inhibits medulloblastoma growth and augments inhibition of smoothened to decrease tumor cell proliferation, thus highlighting Gα(s) as a potential therapeutic target. Taylor & Francis 2014-12-01 /pmc/articles/PMC4905062/ /pubmed/27308425 http://dx.doi.org/10.4161/23723556.2014.975070 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
He, Xuelian
Lu, Q. Richard
G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title_full G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title_fullStr G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title_full_unstemmed G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title_short G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
title_sort g-protein gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905062/
https://www.ncbi.nlm.nih.gov/pubmed/27308425
http://dx.doi.org/10.4161/23723556.2014.975070
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