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G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling

We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP i...

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Detalles Bibliográficos
Autores principales: He, Xuelian, Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905062/
https://www.ncbi.nlm.nih.gov/pubmed/27308425
http://dx.doi.org/10.4161/23723556.2014.975070

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