BIM's up first

In vivo analysis of the genetic determinants of Myc-induced apoptosis reveals a specific requirement for the Bcl2 family protein Bim (Bcl2l11). Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of se...

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Detalles Bibliográficos
Autores principales: Murphy, Daniel J., Muthalagu, Nathiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Bim's up First
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905064/
https://www.ncbi.nlm.nih.gov/pubmed/27308426
http://dx.doi.org/10.4161/23723556.2014.975083
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author Murphy, Daniel J.
Muthalagu, Nathiya
author_facet Murphy, Daniel J.
Muthalagu, Nathiya
author_sort Murphy, Daniel J.
collection PubMed
description In vivo analysis of the genetic determinants of Myc-induced apoptosis reveals a specific requirement for the Bcl2 family protein Bim (Bcl2l11). Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of sensitization by Myc to death induced by DNA damage.
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spelling pubmed-49050642016-06-15 BIM's up first Murphy, Daniel J. Muthalagu, Nathiya Mol Cell Oncol Bim's up First In vivo analysis of the genetic determinants of Myc-induced apoptosis reveals a specific requirement for the Bcl2 family protein Bim (Bcl2l11). Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of sensitization by Myc to death induced by DNA damage. Taylor & Francis 2014-12-01 /pmc/articles/PMC4905064/ /pubmed/27308426 http://dx.doi.org/10.4161/23723556.2014.975083 Text en © 2015 Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Bim's up First
Murphy, Daniel J.
Muthalagu, Nathiya
BIM's up first
title BIM's up first
title_full BIM's up first
title_fullStr BIM's up first
title_full_unstemmed BIM's up first
title_short BIM's up first
title_sort bim's up first
topic Bim's up First
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905064/
https://www.ncbi.nlm.nih.gov/pubmed/27308426
http://dx.doi.org/10.4161/23723556.2014.975083
work_keys_str_mv AT murphydanielj bimsupfirst
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