Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140

Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colo...

Descripción completa

Detalles Bibliográficos
Autores principales: Cavaillès, Vincent, Lapierre, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905177/
https://www.ncbi.nlm.nih.gov/pubmed/27308333
http://dx.doi.org/10.4161/23723548.2014.960761
Descripción
Sumario:Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.

Ejemplares similares