Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140

Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colo...

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Detalles Bibliográficos
Autores principales: Cavaillès, Vincent, Lapierre, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905177/
https://www.ncbi.nlm.nih.gov/pubmed/27308333
http://dx.doi.org/10.4161/23723548.2014.960761
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author Cavaillès, Vincent
Lapierre, Marion
author_facet Cavaillès, Vincent
Lapierre, Marion
author_sort Cavaillès, Vincent
collection PubMed
description Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.
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spelling pubmed-49051772016-06-15 Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140 Cavaillès, Vincent Lapierre, Marion Mol Cell Oncol Author's View Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation. Taylor & Francis 2014-10-31 /pmc/articles/PMC4905177/ /pubmed/27308333 http://dx.doi.org/10.4161/23723548.2014.960761 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Cavaillès, Vincent
Lapierre, Marion
Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title_full Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title_fullStr Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title_full_unstemmed Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title_short Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
title_sort regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator rip140
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905177/
https://www.ncbi.nlm.nih.gov/pubmed/27308333
http://dx.doi.org/10.4161/23723548.2014.960761
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