The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition

In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summa...

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Detalles Bibliográficos
Autores principales: Feng, Yu-xiong, Sokol, Ethan S, Gupta, Piyush B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905182/
https://www.ncbi.nlm.nih.gov/pubmed/27308337
http://dx.doi.org/10.4161/23723548.2014.961822
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author Feng, Yu-xiong
Sokol, Ethan S
Gupta, Piyush B
author_facet Feng, Yu-xiong
Sokol, Ethan S
Gupta, Piyush B
author_sort Feng, Yu-xiong
collection PubMed
description In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings.
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spelling pubmed-49051822016-06-15 The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition Feng, Yu-xiong Sokol, Ethan S Gupta, Piyush B Mol Cell Oncol Author's View In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905182/ /pubmed/27308337 http://dx.doi.org/10.4161/23723548.2014.961822 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Feng, Yu-xiong
Sokol, Ethan S
Gupta, Piyush B
The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title_full The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title_fullStr The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title_full_unstemmed The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title_short The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
title_sort endoplasmic reticulum may be an achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905182/
https://www.ncbi.nlm.nih.gov/pubmed/27308337
http://dx.doi.org/10.4161/23723548.2014.961822
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