Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells

S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author&...

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Detalles Bibliográficos
Autor principal: Meuth, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905207/
https://www.ncbi.nlm.nih.gov/pubmed/27308366
http://dx.doi.org/10.4161/23723548.2014.968508
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author Meuth, Mark
author_facet Meuth, Mark
author_sort Meuth, Mark
collection PubMed
description S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed.
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spelling pubmed-49052072016-06-15 Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells Meuth, Mark Mol Cell Oncol Author's View S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed. Taylor & Francis 2014-12-31 /pmc/articles/PMC4905207/ /pubmed/27308366 http://dx.doi.org/10.4161/23723548.2014.968508 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Meuth, Mark
Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title_full Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title_fullStr Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title_full_unstemmed Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title_short Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells
title_sort inhibitors of cell cycle checkpoints and dna replication cause different responses in normal versus malignant urothelial cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905207/
https://www.ncbi.nlm.nih.gov/pubmed/27308366
http://dx.doi.org/10.4161/23723548.2014.968508
work_keys_str_mv AT meuthmark inhibitorsofcellcyclecheckpointsanddnareplicationcausedifferentresponsesinnormalversusmalignanturothelialcells

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