Unexpected mechanisms of action for a cytokine receptor-blocking antibody

CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts “open” and “closed” conformations. CSL362 blocks IL-3 function t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hercus, Timothy R, Broughton, Sophie E, Hardy, Matthew P, Nero, Tracy L, Wilson, Nicholas J, Parker, Michael W, Lopez, Angel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208/
https://www.ncbi.nlm.nih.gov/pubmed/27308368
http://dx.doi.org/10.4161/23288604.2014.969129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208/
https://www.ncbi.nlm.nih.gov/pubmed/27308368
http://dx.doi.org/10.4161/23288604.2014.969129

Ejemplares similares