Unexpected mechanisms of action for a cytokine receptor-blocking antibody

CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts “open” and “closed” conformations. CSL362 blocks IL-3 function t...

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Autores principales: Hercus, Timothy R, Broughton, Sophie E, Hardy, Matthew P, Nero, Tracy L, Wilson, Nicholas J, Parker, Michael W, Lopez, Angel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208/
https://www.ncbi.nlm.nih.gov/pubmed/27308368
http://dx.doi.org/10.4161/23288604.2014.969129
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author Hercus, Timothy R
Broughton, Sophie E
Hardy, Matthew P
Nero, Tracy L
Wilson, Nicholas J
Parker, Michael W
Lopez, Angel F
author_facet Hercus, Timothy R
Broughton, Sophie E
Hardy, Matthew P
Nero, Tracy L
Wilson, Nicholas J
Parker, Michael W
Lopez, Angel F
author_sort Hercus, Timothy R
collection PubMed
description CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts “open” and “closed” conformations. CSL362 blocks IL-3 function through both IL3Rα conformations but via distinct and unexpected mechanisms.
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spelling pubmed-49052082016-06-15 Unexpected mechanisms of action for a cytokine receptor-blocking antibody Hercus, Timothy R Broughton, Sophie E Hardy, Matthew P Nero, Tracy L Wilson, Nicholas J Parker, Michael W Lopez, Angel F Mol Cell Oncol Commentary CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts “open” and “closed” conformations. CSL362 blocks IL-3 function through both IL3Rα conformations but via distinct and unexpected mechanisms. Taylor & Francis 2014-12-31 /pmc/articles/PMC4905208/ /pubmed/27308368 http://dx.doi.org/10.4161/23288604.2014.969129 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Hercus, Timothy R
Broughton, Sophie E
Hardy, Matthew P
Nero, Tracy L
Wilson, Nicholas J
Parker, Michael W
Lopez, Angel F
Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title_full Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title_fullStr Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title_full_unstemmed Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title_short Unexpected mechanisms of action for a cytokine receptor-blocking antibody
title_sort unexpected mechanisms of action for a cytokine receptor-blocking antibody
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208/
https://www.ncbi.nlm.nih.gov/pubmed/27308368
http://dx.doi.org/10.4161/23288604.2014.969129
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