Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

Statins are promising anticancer agents that target the mevalonate pathway. Tumor cells are sensitive to depletion of mevalonate-derived products but this activity triggers a homeostatic feedback loop that blunts statin efficacy. We showed that dipyridamole inhibits this feedback response and potent...

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Detalles Bibliográficos
Autores principales: Pandyra, Aleksandra, Penn, Linda Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905210/
https://www.ncbi.nlm.nih.gov/pubmed/27308369
http://dx.doi.org/10.4161/23723548.2014.969133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905210/
https://www.ncbi.nlm.nih.gov/pubmed/27308369
http://dx.doi.org/10.4161/23723548.2014.969133

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