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Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

Statins are promising anticancer agents that target the mevalonate pathway. Tumor cells are sensitive to depletion of mevalonate-derived products but this activity triggers a homeostatic feedback loop that blunts statin efficacy. We showed that dipyridamole inhibits this feedback response and potent...

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Detalles Bibliográficos
Autores principales:	Pandyra, Aleksandra, Penn, Linda Z
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905210/ https://www.ncbi.nlm.nih.gov/pubmed/27308369 http://dx.doi.org/10.4161/23723548.2014.969133

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