Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival

Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the glycolytic regulator HIF-1α and...

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Detalles Bibliográficos
Autores principales: Ferrer, Christina M, Reginato, Mauricio J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905223/
https://www.ncbi.nlm.nih.gov/pubmed/27308381
http://dx.doi.org/10.4161/23723548.2014.961809
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author Ferrer, Christina M
Reginato, Mauricio J
author_facet Ferrer, Christina M
Reginato, Mauricio J
author_sort Ferrer, Christina M
collection PubMed
description Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the glycolytic regulator HIF-1α and links metabolism to stress and cancer cell survival.
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spelling pubmed-49052232016-06-15 Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival Ferrer, Christina M Reginato, Mauricio J Mol Cell Oncol Author's View Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the glycolytic regulator HIF-1α and links metabolism to stress and cancer cell survival. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905223/ /pubmed/27308381 http://dx.doi.org/10.4161/23723548.2014.961809 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ferrer, Christina M
Reginato, Mauricio J
Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title_full Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title_fullStr Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title_full_unstemmed Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title_short Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
title_sort sweet connections: o-glcnacylation links cancer cell metabolism and survival
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905223/
https://www.ncbi.nlm.nih.gov/pubmed/27308381
http://dx.doi.org/10.4161/23723548.2014.961809
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