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The retinoblastoma protein: multitasking to suppress tumorigenesis

Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to sup...

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Detalles Bibliográficos
Autores principales: Vormer, Tinke L., Hansen, Jacob B, te Riele, Hein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905230/
https://www.ncbi.nlm.nih.gov/pubmed/27308398
http://dx.doi.org/10.4161/23723548.2014.968062