The retinoblastoma protein: multitasking to suppress tumorigenesis

Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to sup...

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Detalles Bibliográficos
Autores principales: Vormer, Tinke L., Hansen, Jacob B, te Riele, Hein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905230/
https://www.ncbi.nlm.nih.gov/pubmed/27308398
http://dx.doi.org/10.4161/23723548.2014.968062
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author Vormer, Tinke L.
Hansen, Jacob B
te Riele, Hein
author_facet Vormer, Tinke L.
Hansen, Jacob B
te Riele, Hein
author_sort Vormer, Tinke L.
collection PubMed
description Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.
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spelling pubmed-49052302016-06-15 The retinoblastoma protein: multitasking to suppress tumorigenesis Vormer, Tinke L. Hansen, Jacob B te Riele, Hein Mol Cell Oncol Author's View Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions. Taylor & Francis 2015-01-26 /pmc/articles/PMC4905230/ /pubmed/27308398 http://dx.doi.org/10.4161/23723548.2014.968062 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Vormer, Tinke L.
Hansen, Jacob B
te Riele, Hein
The retinoblastoma protein: multitasking to suppress tumorigenesis
title The retinoblastoma protein: multitasking to suppress tumorigenesis
title_full The retinoblastoma protein: multitasking to suppress tumorigenesis
title_fullStr The retinoblastoma protein: multitasking to suppress tumorigenesis
title_full_unstemmed The retinoblastoma protein: multitasking to suppress tumorigenesis
title_short The retinoblastoma protein: multitasking to suppress tumorigenesis
title_sort retinoblastoma protein: multitasking to suppress tumorigenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905230/
https://www.ncbi.nlm.nih.gov/pubmed/27308398
http://dx.doi.org/10.4161/23723548.2014.968062
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