Induction of pyroptosis in colon cancer cells by LXRβ

Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in...

Descripción completa

Detalles Bibliográficos
Autores principales: Rébé, Cédric, Derangère, Valentin, Ghiringhelli, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905240/
https://www.ncbi.nlm.nih.gov/pubmed/27308405
http://dx.doi.org/10.4161/23723548.2014.970094
_version_ 1782437234866126848
author Rébé, Cédric
Derangère, Valentin
Ghiringhelli, François
author_facet Rébé, Cédric
Derangère, Valentin
Ghiringhelli, François
author_sort Rébé, Cédric
collection PubMed
description Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in cancer treatment.
format Online
Article
Text
id pubmed-4905240
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49052402016-06-15 Induction of pyroptosis in colon cancer cells by LXRβ Rébé, Cédric Derangère, Valentin Ghiringhelli, François Mol Cell Oncol Author's View Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in cancer treatment. Taylor & Francis 2015-02-24 /pmc/articles/PMC4905240/ /pubmed/27308405 http://dx.doi.org/10.4161/23723548.2014.970094 Text en Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Rébé, Cédric
Derangère, Valentin
Ghiringhelli, François
Induction of pyroptosis in colon cancer cells by LXRβ
title Induction of pyroptosis in colon cancer cells by LXRβ
title_full Induction of pyroptosis in colon cancer cells by LXRβ
title_fullStr Induction of pyroptosis in colon cancer cells by LXRβ
title_full_unstemmed Induction of pyroptosis in colon cancer cells by LXRβ
title_short Induction of pyroptosis in colon cancer cells by LXRβ
title_sort induction of pyroptosis in colon cancer cells by lxrβ
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905240/
https://www.ncbi.nlm.nih.gov/pubmed/27308405
http://dx.doi.org/10.4161/23723548.2014.970094
work_keys_str_mv AT rebecedric inductionofpyroptosisincoloncancercellsbylxrb
AT derangerevalentin inductionofpyroptosisincoloncancercellsbylxrb
AT ghiringhellifrancois inductionofpyroptosisincoloncancercellsbylxrb

Ejemplares similares