Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease

DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the po...

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Detalles Bibliográficos
Autor principal: Oberdoerffer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905243/
https://www.ncbi.nlm.nih.gov/pubmed/27308388
http://dx.doi.org/10.4161/23723548.2014.970952
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author Oberdoerffer, Philipp
author_facet Oberdoerffer, Philipp
author_sort Oberdoerffer, Philipp
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description DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the possible implications for cell functions beyond repair.
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spelling pubmed-49052432016-06-15 Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease Oberdoerffer, Philipp Mol Cell Oncol Author's View DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the possible implications for cell functions beyond repair. Taylor & Francis 2014-12-01 /pmc/articles/PMC4905243/ /pubmed/27308388 http://dx.doi.org/10.4161/23723548.2014.970952 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Oberdoerffer, Philipp
Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title_full Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title_fullStr Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title_full_unstemmed Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title_short Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
title_sort stop relaxing: how dna damage-induced chromatin compaction may affect epigenetic integrity and disease
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905243/
https://www.ncbi.nlm.nih.gov/pubmed/27308388
http://dx.doi.org/10.4161/23723548.2014.970952
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