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Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the po...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905243/ https://www.ncbi.nlm.nih.gov/pubmed/27308388 http://dx.doi.org/10.4161/23723548.2014.970952 |