Cargando…
Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated te...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905247/ https://www.ncbi.nlm.nih.gov/pubmed/27308409 http://dx.doi.org/10.4161/23723556.2014.975623 |