Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated te...

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Detalles Bibliográficos
Autores principales: Hendrickson, Eric A, Baird, Duncan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905247/
https://www.ncbi.nlm.nih.gov/pubmed/27308409
http://dx.doi.org/10.4161/23723556.2014.975623
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author Hendrickson, Eric A
Baird, Duncan M
author_facet Hendrickson, Eric A
Baird, Duncan M
author_sort Hendrickson, Eric A
collection PubMed
description Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.
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spelling pubmed-49052472016-06-15 Alternative end joining, clonal evolution, and escape from a telomere-driven crisis Hendrickson, Eric A Baird, Duncan M Mol Cell Oncol Author's View Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution. Taylor & Francis 2015-01-28 /pmc/articles/PMC4905247/ /pubmed/27308409 http://dx.doi.org/10.4161/23723556.2014.975623 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Hendrickson, Eric A
Baird, Duncan M
Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title_full Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title_fullStr Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title_full_unstemmed Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title_short Alternative end joining, clonal evolution, and escape from a telomere-driven crisis
title_sort alternative end joining, clonal evolution, and escape from a telomere-driven crisis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905247/
https://www.ncbi.nlm.nih.gov/pubmed/27308409
http://dx.doi.org/10.4161/23723556.2014.975623
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