A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

Bisphosphonate drugs such as zoledronic acid (ZOL), used for the treatment of common bone disorders, target the skeleton and inhibit bone resorption by preventing the prenylation of small GTPases in bone-destroying osteoclasts. Increasing evidence indicates that bisphosphonates also have pleiotropic...

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Detalles Bibliográficos
Autores principales: Ali, Naveid, Jurczyluk, Julie, Shay, Gemma, Tnimov, Zakir, Alexandrov, Kirill, Munoz, Marcia A, Skinner, Oliver P, Pavlos, Nathan J, Rogers, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905276/
https://www.ncbi.nlm.nih.gov/pubmed/26399387
http://dx.doi.org/10.1080/21541248.2015.1085485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905276/
https://www.ncbi.nlm.nih.gov/pubmed/26399387
http://dx.doi.org/10.1080/21541248.2015.1085485

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