Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition

Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting Ox...

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Detalles Bibliográficos
Autores principales: McQuade, Jennifer L, Vashisht Gopal, Yn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905309/
https://www.ncbi.nlm.nih.gov/pubmed/27308473
http://dx.doi.org/10.4161/23723556.2014.991610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905309/
https://www.ncbi.nlm.nih.gov/pubmed/27308473
http://dx.doi.org/10.4161/23723556.2014.991610

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